DNA/RNA Synthesis Modulator

DNA/RNA Synthesis Modulators (20):

Cat. No.	Product Name	Effect	Purity

HY-112633

SMN-C3	Modulator	99.89%
SMN-C3 is an orally active *SMN2* splicing modulator and has the potential to treat spinal muscular atrophy (SMA).

HY-101792

RG7800	Modulator	99.86%
RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.

HY-101792A

RG7800 tetrahydrochloride	Modulator	99.61%
RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC_1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.

HY-124713

ML372	Modulator	99.43%
ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo.

HY-15620

Methylproamine	Modulator	99.90%
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks.

HY-145973A

3'OMe-m7GpppAmpG ammonium	Modulator	≥99.0%
3'OMe-m7GpppAmpG ammonium is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization.

HY-111517

H3B-8800	Modulator
H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant.

HY-145974A

m7GpppAmpG ammonium	Modulator	≥99.0%
m7GpppAmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 90%.

HY-150248

RNA splicing modulator 3	Modulator
RNA splicing modulator 3 (compound 236) is a RNA splicing modulator, with an AC₅₀ value of <100 nM.

HY-150144

Uracil-m7GpppAmpG ammonium	Modulator
Uracil-m7GpppAmpG ammonium is a cap analog that can be used for mRNA synthesis.

HY-150246

RNA splicing modulator 1	Modulator
RNA splicing modulator 1 (compound 233) is a RNA splicing modulator, with an AC₅₀ value of <100 nM.

HY-N10579

Chrexanthomycin C	Modulator
Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity for DNA (G4C2)⁴ G4 with a K_d value of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS).

HY-145977A

m7GpppGmpG ammonium	Modulator
m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.

HY-156650

Votoplam	Modulator
Votoplam is a gene splicing modulator, used to inhibit Huntington's disease.

HY-145977

m7GpppGmpG	Modulator
m7GpppGmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.

HY-150247

RNA splicing modulator 2	Modulator
RNA splicing modulator 2 (compound 256) is a RNA splicing modulator.

HY-139099

Diguanosine 5′-triphosphate	Modulator
Diguanosine 5′-triphosphate (Gp3G) is a dinucleoside triphosphates. Diguanosine 5′-triphosphate also is a virus-specific oligonucleotide. Diguanosine 5′-triphosphate is needed for the synthesis of RNA during the transcription process.

HY-145973

3'OMe-m7GpppAmpG	Modulator
3'OMe-m7GpppAmpG is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG shows a significant translational efficiency. 3'OMe-m7GpppAmpG can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization.

HY-139099A

Diguanosine 5′-triphosphate lithium	Modulator
Diguanosine 5′-triphosphate (Gp3G) lithium is a dinucleoside triphosphates. Diguanosine 5′-triphosphate lithium also is a virus-specific oligonucleotide. Diguanosine 5′-triphosphate lithium is needed for the synthesis of RNA during the transcription process.

HY-145974

m7GpppAmpG	Modulator
m7GpppAmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 90%.

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